switchSENSE® TECH DAYS, Pro-Environment Polska Sp. z o.o., wtorek, 07. maj 2019

switchSENSE® TECH DAYS –BIOSENSING WITH ELECTRO-SWITCHABLE BIOSURFACES
switchSENSE® is an automated biosensor chip technology that employs electrically actuated DNA nanolevers for the real-time measurement of binding kinetics (kON, kOFF) and affinities (KD). Interactions between proteins, DNA/RNA, and small molecules can be detected with high sensitivity. Application examples of protein – protein, small molecule – DNA, sizing and conformational changes will be presented.

PROGRAMSCIENTIFIC TALKS  I  TECHNICAL TUTORIALS  I  HANDS-ON EXPERIMENTS
Tuesday, May 07thPROTEIN-DNA INTERACTIONSAptamers | Powerful tool for fast and easy diagnostics
10:00am switchSENSE® scientific presentation  11:00am Hands-on switchSENSE® experiments: Real-time investigation of thrombin interaction with DNA aptamers

Wednesday, May 08thPROTEIN-SMALL MOLECULES INTERACTIONS
Small Molecules | Go beyond KD determination in drug discovery process
10:00am switchSENSE® scientific presentation 11:00am Hands-on switchSENSE® experiments: Protein interaction with small molecules using electrically actuated  DNA nanolevers

Thursday, May 09thANTIGEN-ANTIBODY INTERACTIONS
Antibodies | Where off-rates matter
10:00am switchSENSE® scientific presentation 11:00am Hands-on switchSENSE® experiments: Characterization of antibody interactions and hydrodynamic sizing


switchSENSE® technology delivers unrivaled information on a single platform 
dynamicBIOSENSORS’ pioneering switchSENSE® sensor platform is an automated, fluorescence based biosensor chip technology that employs electrically actuated DNA nanolevers for the real-time measurement of binding kinetics (kON, kOFF) and affinities (with KD values down to the fM range). The platform offers an automated ligand density control, which allows to conveniently discriminate between affinity and avidity in one single assay. Interactions between proteins, DNA/RNA, and small molecules can be detected with femto-molar sensitivity. Using minimal amounts of sample, protein diameters (DH) and conformational changes are analyzed with 0.1 nm accuracy, as well as protein melting transitions (TM). As a world’s first, our double color DRX² analyzer enables the simultaneous measurement of two different species of probes on the same detection spot. This offers the possibility of on-spot referencing or dual binding modelling, which is ideal for bispecific and proof-of-action experiments.

wtorek, 07. maj 2019, Pro-Environment Polska Sp. z o.o., switchSENSE® TECH DAYS

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